Manage side effects • Preserve muscle • Build habits that last
Finding the right support for your GLP-1 journey shouldn’t feel overwhelming. That’s why Mayo Clinic experts designed this program—to help you navigate medication with confidence, build lifelong habits, and preserve your health along the way.
When you're using GLP‑1 medication, smart support isn't just helpful—it’s essential. That’s why Mayo Clinic created this tailored program to combine medical expertise with practical tools that help you not just survive but thrive through your medication journey. It’s your full-circle companion for side-effect management, muscle preservation, and lifestyle transformation.
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The Mayo Clinic Diet Weight-Loss Medications Support Program transforms your GLP-1 journey into a structured, expert-supported experience. With targeted programming from Mayo Clinic professionals, it helps you manage medication side effects, safeguard muscle, and develop behaviors that support long-term health—even after you stop using GLP-1s.
Jump-start your journey with quick, motivational results and essential side-effect support:
Deepen your progress with lifestyle-change coaching and healthy habit development:
Tailored specifically for GLP-1 users, this program adds extra support for medication transitions and habit continuity:
NEW IN 2026
Your journey with the Mayo Clinic Diet starts with a plan that fits you—your health, preferences, and lifestyle. The program is designed to make healthy eating simple, enjoyable, and sustainable, no matter your starting point.
Weight loss: 45 lbs*
Since integrating the Mayo Clinic Diet into his daily routine—while taking a GLP-1 weight-loss medication—Dustin not only feels great but loves his renewed lifestyle with his husband and family.
“My doctor explained that taking GLP-1s is a lifelong process. He stressed the importance of changing my habits or the weight would come right back once I stopped taking weight-loss medication. That was not an option for me.”
Hear from others like you.
"This is the easiest diet ever, and it’s a complete program that holds you accountable without stress. It’s about your journey − not comparing yourself to anyone else."
"I’ve been on blood pressure medication since my late 20s, but I no longer need it. It’s an incredible feeling to look in the mirror and feel proud of what you see."
"The program has changed my life completely. I no longer feel like I’m staring down mortality. I have decades of life ahead to love my family and care for future grandchildren."
"My lab results are back to normal, my blood pressure is under control, and my knee and back pain are now gone... Trust the process. It works."
The Mayo Clinic Diet is so easy to follow. I love the different plans you can choose from and swap between. All the recipes are amazing and easy to make. If you don't like an ingredient or recipe, you can swap for something else. I like how there is a gluten free meal plan. This is definitely one diet I will stick to.
The diet, exercise, and behaviors presented through the program helped me reach and maintain my weight loss goal. I could get close on my own but could not break through the final 10 pounds. A key enabler was being able to [freestyle] meal planning while following calorie and nutrition guidance.
For me, Mayo Clinic Diet is perfect. The two-week start takes the guess work out of what to eat. You get grocery lists and simple, satisfying recipes. The encouragement to address habits that inhibit or propel weight loss is also a wonderful feature. The program truly addresses everything you need to succeed.
Your membership is packed with tremendous value that will lead to long-term sustainable weight loss.
The Mayo Clinic Diet Weight-Loss Medications Support Program combines clinician-designed support, habit-focused tools, and community—all tailored for those taking GLP‑1 medication. Unlike stand-alone programs, it's built to reduce side effects, support muscle strength, and foster sustainable habits that help you thrive even after stopping the medication.
Through practical strategies—like smaller, nutrient-dense meals, proper hydration, and texture adjustments—the Mayo Clinic Diet Weight-Loss Medications Support Program helps ease typical GLP‑1 side effects such as nausea, digestive discomfort, and appetite shifts.
The Mayo Clinic Diet Weight-Loss Medications Support Program emphasizes protein-rich meal planning and at-home resistance workouts to preserve lean muscle and metabolic health.
The structured core curriculum lasts 24 weeks, giving you targeted education, tools, and coaching. Our personalized journey helps you plan a full year ahead. But your access doesn’t end there—you retain full program access and support for as long as you choose.
No. The program uses a building-block meal system rather than calorie counting, emphasizing a balanced plate of vegetables, fruits, protein, whole grains and healthy fats. It’s flexible and realistic for real life.
While weight regain is common with GLP-1s, the Mayo Clinic Diet Weight-Loss Medications Support Program is designed to help you build lasting habits that can help prevent weight regain. With structured coaching, community support, and habit tools, it's possible to maintain significant weight loss long-term, even after medication is discontinued.
Absolutely. Members get unlimited group coaching with Mayo Clinic registered dietitians and specialists, covering everything from side-effect strategies to strength-building plans and mental habits.
Extensive clinical research shows that GLP-1 medications can help people lose about 15% of their body weight when combined with healthy lifestyle changes. That is why the FDA has approved these medications as part of a weight management program like the Mayo Clinic Diet. Published studies of the Mayo Clinic Diet also confirm its effectiveness. Participants achieved 80% more weight loss compared to those in a comparable in-person program, and responders lost an average of 13% of their body weight in just 6 months with lifestyle alone.