The Mayo Clinic Diet takes your anti-inflammatory diet to the next level
The Mayo Clinic Diet delivers all the anti-inflammatory power you need: olive oil, fatty fish, nuts, legumes, and colorful vegetables that lower inflammatory markers and support your gut. While the anti-inflammatory diet stops there, the Mayo Clinic Diet takes you further:
- Comprehensive meal plans:
Choose from Mediterranean or the Heart Smart Superfoods meal plans that support an anti-inflammatory way of eating while targeting your specific health goals. - Beyond inflammation alone:
Our program addresses weight, metabolism, heart health, disease prevention, and healthy habits, not just reducing inflammatory markers. - Structured guidance:
A clear 12-week plan with recipes, meal swaps, and grocery lists (anti-inflammatory diets often leave you searching for what to actually eat).
Take the first step
Complete the Mayo Clinic Diet assessment today. This is an essential step towards achieving your weight-loss objectives. Whether you're starting an anti-inflammatory diet, looking for a healthy weight-loss plan, or considering weight-loss medication, discover which of our world-leading solutions is best for you.
Our commitment to your health
The Mayo Clinic Diet emphasizes healthy eating and sustainable behavior modifications. We avoid fad diets and quick fixes, focusing instead on evidence-based strategies designed for long-term success.
The free assessment covers your:
- Diet history and preferences
What's your experience with diet plans? Do you have a preferred eating style? - Lifestyle factors
What matters most to you in a program? What's getting in the way of your weight loss? - Weight loss objectives
What's your starting point? How much weight do you intend to lose? - Health history
Do you have any pre-existing health conditions? Are weight-loss medications an option?
What members say about the Mayo Clinic Diet
Beating heart disease
I really needed help to reach my health goals after my doctor told me I was at risk for heart disease. The Mayo Clinic's meal plans seemed to be a good way to do that, and that's proven to be so true! I go for my follow up blood tests next week and am pretty confident they'll show the improvement I was looking for!
Two thumbs up
Overall, I found the experience extremely, extremely valuable. I am a 43-year-old yo-yo dieter. I have had high blood pressure for the past 15 years... For the very first time, with the Mayo Clinic Diet, I found what I was looking for. I have never eaten so much on a diet plan while still losing weight! Thank you for making such a wonderful tool to change lives for the better!
Life changing
Have spent 40 years yo-yo dieting and have never lost 20 lbs in 12 weeks [like I did on the Mayo Clinic Diet]. Their menus are great, easy to make and filling. I am no longer craving food between meals. This isn't a "diet", it teaches you how to eat to be healthy for the rest of your life. My cholesterol is down from 200 to 145, blood pressure now 120 over 70.
Frequently asked questions
What is a personalized weight loss plan?
A personalized weight loss plan is a tailored approach to weight management that adapts to your individual lifestyle, preferences, and any health conditions you may have. Instead of a one-size-fits-all solution, it provides flexible options that let you choose what works best for your goals and daily routine. At the Mayo Clinic Diet, we use your unique health profile to match you with the right tools, meal plans, and expert guidance—so your path to weight loss is truly your own.
How does the Mayo Clinic Diet create a personalized meal plan for weight loss?
The Mayo Clinic Diet starts by getting to know you—your health goals, past weight loss experiences, dietary preferences, and any medical conditions you may be managing. Based on your profile, we recommend one of our 8 expert-designed meal plans for weight loss. You’re free to switch plans or customize meals anytime, giving you the flexibility to enjoy food you love while making meaningful progress on your health journey.
Which diet programs online are available in 2025?
In 2025, the Mayo Clinic Diet offers four comprehensive online weight loss programs:
- Mayo Clinic Diet—our classic program based on the New York Times best-selling book
- Heart Health program—designed for those managing high blood pressure, cholesterol, or heart disease
- Diabetes program—tailored for people with prediabetes or type 2 diabetes
- Weight-Loss Medications program—for those using GLP-1s and similar medications
As a member, you get full access to all four programs and the digital tools that support them—no extra fees or upgrades required.
What meal plans for weight loss can I choose inside the program?
With the Mayo Clinic Diet, you can choose from 8 delicious, science-backed meal plans for weight loss:
- Simple
- Original
- Higher Protein
- Mediterranean
- Healthy Keto
- Vegetarian
- Heart Smart Superfoods
- Protein Balance for GLP-1s
Three of our most popular plans—Simple, Original, and Mediterranean—are also available in gluten-free versions. Every plan is designed by dietitians to ensure you’re eating well while losing weight safely and sustainably.
How much weight can I expect to lose with a personalized plan?
Most members can expect to lose 6–10 pounds in the first two weeks, and about 5% of their body weight within 3 months. Those who embrace the program lose 13% of their body weight within 6 months. Your results may vary, but with a personalized plan and the right support, meaningful weight loss is absolutely within reach.
Does the program support people using weight-loss medications?
Yes! The Mayo Clinic Diet includes a dedicated 24-week program designed specifically for people using weight-loss medications like GLP-1s. It features a special ebook, The Mayo Clinic Diet for Weight-Loss Medications, along with the exclusive Protein Balance for GLP-1s meal plan. This plan helps you get the nutrition you need to support your medication and your weight loss goals.
What digital tools and coaching are included?
Your membership includes a suite of smart digital tools to help you stay on track, including:
- Daily food, exercise, and habit trackers
- The Diet Score tool, offering real-time feedback on your progress
- Group coaching led by Mayo Clinic experts
- Optional one-on-one sessions with registered dietitians
These tools are designed to make healthy habits easier and more rewarding every day.
How do I get started with my personalized weight loss plan?
It’s easy! Simply become a member by signing up—plans start at just 55 cents per day. Not ready to commit? Try our free Personalized Plan experience to explore your best-fit weight loss options and get a sneak peek at the tools and meal plans that make the Mayo Clinic Diet one of the most trusted weight loss programs online.