Healthy weight loss when 
GLP-1s are not an option

Lose 6-10 lbs in your first 2 weeks with the Mayo Clinic Diet.

Weight-loss medications can help you lose approximately 15% of your body weight in a year, but they’re not for everyone. 
Pre-existing health conditions, side effects and high out-of-pocket costs can limit who can stick to this treatment.

The Mayo Clinic Diet has comparable weight loss to GLP-1s ¹ ²

“Responders” to The Mayo Clinic Diet 
(i.e. those in the top 20% for weight loss) lose 13% of their body weight in 6 months, and initially lose weight faster than adults using weight-loss medication.

How to be a weight loss responder ¹

To achieve greater weight loss using the lifestyle approach:

• Go all-in for the first 3-4 weeks.
• Use The Mayo Clinic Diet meal plans to guide what you eat.
• Track your food and drinks ideally 5 days a week.

3 habits responders practice more ¹

Mayo Clinic Diet responders reported doing these 3 habits more frequently than other members in the early weeks of the program:

References

1. Mayo Clinic Diet - Weight Loss and Platform Usage: An analysis of Responders, Digital Wellness Report, August 2024
2. Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med. 2021;384(11):989-1002.

Already taking GLP-1s? Discover our companion to weight-loss medications from the experts at Mayo Clinic.