Access to weight-loss medications in a
top-rated platform

The Mayo Clinic Diet now offers access to clinical care for members interested in adding weight-loss medications such as GLP-1s to their journey.

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Your companion to weight-loss medication + clinical care


If you're considering adding medication to your weight loss journey but don't have a healthcare provider to support you, we'll be there. You'll be guided by the Mayo Clinic Diet for Weight-Loss Medications program and this clinical care:

Clinical care + check-ins*

A board-certified clinician from Amwell* will help determine if weight-loss medications are right for your journey, and help you stay on track with clinically-monitored digital care.

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Prescriptions and refills

If appropriate, your clinician may prescribe FDA-approved medications for weight-loss such as GLP-1s. They will consider your health history and budget to choose the best option. 

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Insurance support

The clinical team from Amwell* will help you navigate the process, submitting your insurance forms and answering any questions you may have. If your insurer won't cover medication, the clinical team can offer other affordable options.

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Lab test

Membership includes a complimentary lab test to confirm your suitability for weight-loss medication. You can also upload lab tests done within the past 6 months to fast-track the process. (Participating labs only. Not available in NY, NJ, RI).

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*Clinical care provided by the Amwell Medical Group® via the Healthy Weight Platform, exclusive to Mayo Clinic Diet.

15%
Average weight loss with a program like Mayo Clinic Diet and weight-loss medication*
80%
More weight loss from the Mayo Clinic Diet digital program than an in-person experience†
FSA/HSA
Savings account eligible
*Based on a 68-week clinical trial, patients without diabetes but with a BMI of ≥30, or ≥27 lost an average of 15% of their body weight (-33.6 lbs) on 2.4 mg semaglutide, when combined with a reduced-calorie diet and increased physical activity. Wegovy® is FDA-approved for weight management. †Acosta, et al. (2024): Efficacy of In-Person and Digital Lifestyle Interventions in Patients with Overweight and Obesity.

The Mayo Clinic Diet for
Weight-Loss Medications program


Access to clinical care is just one aspect of the program: Mayo Clinic Diet for Weight-Loss Medications provides the structure and support you need to achieve healthy, successful weight loss with medication such as GLP-1s. Membership includes these top-rated features.

Protein Balance meal plan

This higher protein meal plan helps prevent muscle loss associated with GLP-1s. It's just one of the 7 delicious meal plans you'll have access to. 

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Personalized journey

We'll map out your year ahead on weight-loss medication to help you develop skills for sustainable weight loss. Your journey continues even when medication stops.

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Group coaching with Mayo Clinic experts

This is your opportunity to learn from experts and ask questions in real-time. Topics include nutrition, exercise and managing the side effects of weight-loss medication. 

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Weight-loss medications ebook

Membership includes 2 complimentary ebooks: The Mayo Clinic Diet: Weight-Loss Medications Edition and Cook Smart, Eat Well. Enjoy them on your computer, tablet or mobile phone.

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24 weeks of education

Our program covers everything you need to know about losing weight with weight-loss medication and maintaining your goals once you've stopped medication.

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At-home exercise plans

Our resistance exercise plan can help prevent muscle loss, a side effect of weight-loss medication. All workouts can be done at home with no equipment.  

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Easy-to-use tracking tools

Develop the skills for lifelong weight management with 5-star rated food, weight and habit tracking tools that keep you accountable. 

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Community support

Our Private Facebook Group has been described as one of the happiest places on social media. Here, members share the ups, downs and non-scale victories that make the program so popular.

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Designed by experts at Mayo Clinic

The program has been thoughtfully designed by Mayo Clinic physicians and dietitians, including world-renowned obesity expert, Dr. Andres Acosta.

A simple monthly fee

Our Clinical membership combines the Mayo Clinic Diet for Weight-Loss Medications with end-to-end clinical care* for just $99.99 per month, cancel anytime

Our Clinical membership includes:

  • A 24-week support program tailored for weight-loss medication
  • Choice of 7 meal plans including Protein Balance specially designed to prevent muscle loss
  • Live group coaching sessions with Mayo Clinic experts
  • Exclusive ebook The Mayo Clinic Diet: Weight-Loss Medications Edition
  • 1:1 video visits with a board-certified physician from Amwell*
  • Weight-loss medication prescription and refills, if clinically appropriate
  • Lab test to confirm suitability for medication (participating labs only)
  • Help submitting insurance forms for prescriptions
  • Clinical monitoring to ensure you stay on track
  • Weight-loss medication not included

*Clinical care provided by the Amwell Medical Group® via the Healthy Weight Platform, exclusive to Mayo Clinic Diet.

Frequently asked questions

About the program

How does the program work?

The Mayo Clinic Diet for Weight-Loss Medications works by combining a healthy, calorie-controlled diet plan with weight-loss medication. You will discover how to balance your meals, build healthy habits and manage the side effects of weight-loss medications. We offer two subscription options:

What’s included in the Clinical subscription?

  • 1:1 video visits with a board-certified physician from Amwell*
  • Weight-loss medication prescription and refills, if clinically appropriate
  • Lab test from participating labs (not available in NY, NJ, RI)
  • Help submitting insurance forms
  • Clinical monitoring to ensure you stay on track
  • A best-selling diet that is medically-backed and trusted worldwide
  • Protein Balance meal plan designed specifically for members starting GLP-1s
  • Plus, 6 other meal plan options including Healthy Keto, High Protein, Vegetarian and Mediterranean
  • A digital platform that has helped members lose 3x more weight
  • Free Mayo Clinic Diet app available to iOS and Android users
  • Access to the unparalleled educational content and expertise of the Mayo Clinic
  • Mayo Clinic Diet 24-week program to help you learn the principles of healthy weight loss and support you on your weight-loss medication journey
  • Exclusive content and videos from Mayo Clinic doctors and experts
  • Regular live webinars hosted by Mayo Clinic experts
  • A quick start Lose It! phase, where members can lose 6 to 10 lbs in 2 weeks
  • Tools to track progress and log your meals, exercise, measurements, and body weight
  • Quick, easy, healthy, and delicious recipes
  • Habit Optimizer tool to swap unhealthy habits for good ones
  • Protein Balance meal plan designed specifically for members starting GLP-1s. 6 other meal plan options available that include Healthy Keto, High Protein, Vegetarian and Mediterranean
  • Calorie counting not required.
  • Food tracker with over 1m foods
  • Enjoy unlimited fruits and vegetables
  • At-home workouts – no equipment required
  • Psychological quiz to assess diet mindset
  • Unlimited access to a members' Private Facebook Group

*Clinical care provided by the Amwell Medical Group® via the Healthy Weight Platform, exclusive to Mayo Clinic Diet.

How long is the program?

We recommend following the program for a minimum of 6 months and ideally 1 year. Health is a journey and we're here every step of the way, for as long as you need us.

If I am already a member, can I switch to the Weight-Loss Medication program?

Yes, please contact our Member Success team and they will help you through the options.

Pricing, insurance and cost questions

How much does the Clinical subscription cost?

A Clinical membership to Mayo Clinic Diet for Weight-Loss Medications costs $129.99 per month plus a $99.99 start fee. For a limited time, you can join for just $99.99 per month, cancel anytime. View our pricing page for the latest pricing and offers.

Does the Mayo Clinic Diet take insurance?

The Mayo Clinic Diet program does not currently take insurance although you may be able to use HSA/FSA funds to pay for the program. Weight-loss medications may be covered by your insurer. If you have purchased the Clinical subscription, the clinical team from Amwell will submit the relevant forms to help you gain insurance coverage for medication. We recommend contacting your insurer to find out if your plan covers weight-management medications.

Is the medication cost included in my membership fee?

No. The cost of medication is a separate expense that is not included in the membership fee. If you purchase the Clinical subscription, the clinical care team will submit insurance forms for the prescription on your behalf. We also recommend contacting your insurer to find out if your plan covers weight-loss medications.

Is the cost of physician appointments included in the membership fee?

Yes. Your Clinical subscription includes initial and follow-up visits with a physician from Amwell. Your schedule of visits may vary depending on your specific needs but typically you will see a physician when starting the program, at 3 months, 6 months and 12 months. You can message your provider between visits. If you have to see a provider to discuss side effects or challenges with your medication, these extra appointments will also be covered as part of your membership fee, within reason. If you need to reschedule an appointment, please do so at least 24 hours before the scheduled time to avoid additional fees.

Medication questions

Does the Mayo Clinic Diet recommend specific weight-loss medications?

During your initial visit with a clinician from Amwell, you will be evaluated for appropriateness of medication based on several guidelines. These guidelines are intended to help the provider decide the pharmacologic intervention most appropriate for you. All medications prescribed as part of the program are FDA approved. (Note: While phentermine is an FDA-approved drug, it is a controlled substance, so any phentermine-containing product cannot be prescribed via a telehealth provider.)

How do weight-loss medications work?

Medications approved by the FDA for the treatment of obesity work primarily by reducing appetite and increasing feelings of fullness. This leads you to consume fewer calories than your body needs to maintain its weight, resulting in weight loss. It is important to follow a healthy weight management plan like Mayo Clinic Diet while using weight-loss medication to prevent regaining the weight when medication stops.

What medications are currently FDA-approved and used for weight management?

  • Semaglutide (Ozempic, Rybelsus, Wegovy)
  • Tirzepatide (Zepbound, Mounjaro)
  • Liraglutide (Saxenda)
  • Phentermine-topiramate (Qsymia)
  • Orlistat (Alli, Xenical)
  • Naltrexone-Bupropion (Contrave)
  • Setmelanotide (Imcivree)

Note: While phentermine is an FDA-approved drug, it is a controlled substance; any phentermine-containing product cannot be prescribed via a telehealth provider.