Mayo Clinic Diet Medical Weight Loss Rx Program

Complete clinical weight management that combines our proven online program with access to weight loss medications.

      Am I eligible     →

Average weight loss with weight-loss medication*
Medications, if clinically appropriate
Savings account eligible
*Based on a 68-week clinical trial, patients without diabetes but with a BMI of ≥30, or ≥27 lost an average of 15% of their body weight (-33.6 lbs) on 2.4 mg semaglutide, when combined with a reduced-calorie diet and increased physical activity. Wegovy® is FDA-approved for weight management.

How it works

How it works

  1. Take our 30-second quiz to find out if you are eligible.
  2. Register for the program and book an appointment.
  3. Meet your physician and discuss the best medication options.
  4. Start your program!
Am I eligible?
How it works

Powerful, personalized programs for lasting, transformative weight loss

Clinical care + check-ins provided by Amwell†
A board-certified clinician from Amwell will help you find the right weight-loss medication, and support your journey to a healthy weight.

Prescriptions + refills
If appropriate, your clinician may prescribe FDA-approved medications like GLP-1s.

Care coordinator
Our team will help you navigate the process, and are available to answer any questions.

5-star rated app + online program
Our easy-to-use tools will help you develop the healthy habits needed to keep the weight off.

Delicious meals plans + recipes
Choose from 6 menus, including one specially designed for 
weight-loss medication.

At-home fitness plans
Featuring resistance exercises to help maintain muscle, which can be lost while using weight-loss medication.

Supportive online community + group coaching
Access group coaching, dedicated customer service support, and an encouraging Facebook group with over 18,000 members just like you.

†Clinical care provided by the Amwell Medical Group® via the Healthy Weight Platform, exclusive to Mayo Clinic Diet.


Weight loss medications are not an easy way out. They are not a magic banish our extra weight. These medications help us to stick to a low calorie diet, fight back hunger, and make us feel full. That way, it is easier to commit to these important lifestyle changes.

Andres J. Acosta, M.D., Ph.D.

The Mayo Clinic Diet is a lifelong, sustainable approach to weight loss

Whole health nutrition

The Mayo Clinic Diet focuses on getting enough of the right foods, making healthy eating straightforward and seamless.

Life-long, sustainable behavior change

We believe in the power of building sustainable healthy habits. Our program and accountability tools support you, wherever you are on your journey.

Science-backed guidance

The Mayo Clinic Diet is built on decades of medical research and evidence-based strategies for healthy weight loss, as well as the New York Times bestseller, "The Mayo Clinic Diet."

Leading medical authorities

With the Mayo Clinic Diet, you gain access to a network of experts dedicated to supporting your weight loss journey with strategies that go beyond the scale.

What our members say

Join the community

Frequently asked questions

About the Medical Weight Loss Rx program

How does the Mayo Clinic Diet Rx program work?

The Mayo Clinic Diet Rx program works by combining a healthy, calorie-controlled diet plan with weight-loss medication and clinical care. You will discover how to balance your meals, build healthy habits and manage the side effects of weight-loss medications. We offer two program options:

What’s included in the Medical Weight Loss Rx program?

  • 1:1 video visits with a board-certified physician from Amwell*
  • Weight-loss medication prescription and refills, if clinically appropriate
  • Help submitting insurance forms
  • Clinical monitoring to ensure you stay on track
  • A best-selling diet that is medically-backed and trusted worldwide
  • A digital platform that has helped members lose 3x more weight
  • Free Mayo Clinic Diet app available to iOS and Android users
  • Access to the unparalleled educational content and expertise of the Mayo Clinic
  • Mayo Clinic Diet 24 Week Course to help you learn the principles of healthy weight loss to support you on your weight-loss medication journey
  • Exclusive content and videos from Mayo Clinic doctors and experts
  • Regular live webinars hosted by Mayo Clinic experts
  • A quick start Lose It! phase, where members can lose 6 to 10 lbs in 2 weeks
  • Tools to track progress and log your meals, exercise, measurements, and body weight
  • Quick, easy, healthy, and delicious recipes
  • Habit Optimizer tool to swap unhealthy habits for good ones
  • Meal plan designed specifically for members starting GLP-1s. 6 other meal plan options available that include Healthy Keto, High Protein, Vegetarian and Mediterranean
  • Calorie counting not required
  • Food tracker with over 1m foods
  • Enjoy unlimited fruits and vegetables
  • At-home workouts – no equipment required
  • Psychological quiz to assess diet mindset
  • Unlimited access to a members' Private Facebook Group

*Clinical care provided by the Amwell Medical Group® via the Healthy Weight Platform, exclusive to Mayo Clinic Diet.

How long is the program?

We recommend following the program for a minimum of 6 months and ideally 1 year. Health is a journey and we're here every step of the way, for as long as you need us.

If I am already a member, can I switch to the Mayo Clinic Diet Rx program?

Yes, please contact our Member Success team and they will help you through the options.

Pricing, insurance and cost questions

How much does the Medical Weight Loss Rx program cost?

The Mayo Clinic Diet Medical Weight Loss Rx program costs at $129.99 per month plus a $99.99 start fee. If you commit to 6 or 12 months and pay upfront, the price reduces to $89.99 or $79.99 per month respectively, plus a $99.99 start fee. While the program is in beta, the monthly fee will be reduced by $20 per month. View our pricing page for the latest pricing.

Does the Mayo Clinic Diet take insurance?

The Mayo Clinic Diet program does not currently take insurance although you may be able to use HSA/FSA funds to pay for the program. Weight-loss medications may be covered by your insurer. If you are participating in the Medical Weight Loss Rx program, we will submit the relevant forms to help gain you insurance coverage for medication. We recommend contacting your insurer to find out if your plan covers weight-management medications.

Is the medication cost included in my membership fee?

No. The cost of medication is a separate expense that is not included in the membership fee. If you purchase the Medical Weight Loss Rx program, the clinical care team will submit insurance forms for the prescription on your behalf. We also recommend contacting your insurer to find out if your plan covers weight-loss medications.

Is the cost of physician appointments included in the membership fee?

Yes. Your Medical Weight Loss Rx membership includes initial and follow-up visits with a physician from Amwell. Your schedule of visits may vary depending on your specific needs but typically you will see a physician when starting the program, at 3 months, 6 months and 12 months. You can message your provider between visits. If you have to see a provider to discuss side effects or challenges with your medication, these extra appointments will also be covered as part of your membership fee, within reason. If you need to reschedule an appointment, please do at least 24 hours before the scheduled time to avoid additional fees.

Medication questions

Does the Mayo Clinic Diet recommend specific weight-loss medications?

During your initial visit with a clinician from Amwell, you will be evaluated for appropriateness of medication based on several guidelines. These guidelines are intended to help the provider decide the pharmacologic intervention most appropriate for you. All medications prescribed as part of the Medical Weight Loss Rx program are FDA approved. (Note: While phentermine is an FDA-approved drug, it is a controlled substance and so any phentermine-containing product cannot be prescribed via a telehealth provider.)

How do weight-loss medications work?

Medications approved by the FDA for the treatment of obesity work primarily by reducing appetite and increasing feelings of fullness. This leads you to consume fewer calories than your body needs to maintain its weight, resulting in weight loss. It is important to follow a healthy weight management plan like Mayo Clinic Diet while using weight-loss medication to prevent regaining the weight when medication stops.

What medications are currently FDA-approved and used for weight management?

  • Semaglutide (Ozempic, Rybelsus, Wegovy)
  • Tirzepatide (Zepbound)
  • Liraglutide (Saxenda)
  • Phentermine-topiramate (Qsymia)
  • Orlistat (Alli, Xenical)
  • Naltrexone-Bupropion (Contrave)
  • Setmelanotide (Imcivree)

(Note: While phentermine is an FDA-approved drug, it is a controlled substance and so any phentermine-containing product cannot be prescribed via a telehealth provider.)