The best place to inject Mounjaro for weight loss

There's a healthier way to lose weight with weight-loss medication. Discover the Mayo Clinic Diet for Weight-Loss Medications.

Mounjaro, or tirzepatide, is a prescription drug approved by the FDA to treat type 2 diabetes. Although not officially approved for weight loss medication, people with diabetes have lost significant weight while using Mounjaro. This has led doctors to prescribe the drug off-label for weight loss. 

How does a Mounjaro injection work?

Mounjaro triggers the activation of glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonists within the body. When combined with a diet and exercise program, Mounjaro improves glycemic control in adults with type 2 diabetes. The drug mimics hormones found naturally in your body, making you feel full and eat less, helping with weight loss. 

Many people have reported feeling more satisfied with smaller portions and experiencing fewer cravings while taking Mounjaro.   

This can lead to a decrease in calorie intake, which ultimately results in weight loss. Mounjaro also helps control blood sugar levels preventing the body from storing extra glucose as fat.   

Using Mounjaro with a healthcare provider's supervision is important. It may not be safe for everyone and could cause side effects. 

Where to inject Mounjaro

Mounjaro is administered as a subcutaneous (under the skin) injection. Your healthcare professional can help you choose the injection site that is best for you. You or another person can administer Mounjaro into one of the following injection sites: 

Abdomen: The abdomen is often suggested as an injection site because of its vast surface area and easy reach. The subcutaneous fat layer in this area facilitates effective absorption of Mounjaro. When administering Mounjaro in the abdomen, choose a location roughly two inches away from the belly button.  

Thigh: The thigh is a good spot for injections because it also has enough fat for subcutaneous injections. Choose an area on the front of the thigh and avoid injecting the inner thigh. 

Upper arm: The back of the upper arm is another option, particularly for individuals who prefer injecting in a less visible area. For injections in the upper arm, select an injection location between the elbow and shoulder. If you choose this injection site, someone else should administer it. 

Correct technique for Mounjaro injection

  • Preparing for the injection – assemble all necessary items, sanitize hands, inspect the medication for any irregularities. The fluid in the pen should be transparent and colorless to slightly yellow. Do not use if it appears cloudy, discolored, or contains particles.   
  • Choose the injection site, which can be either the stomach, thigh, or upper arm.   
  • Clean the site - utilize an alcohol pad to sanitize the chosen injection area. 
  • Administer the drug - hold the syringe straight against the skin. Quickly insert a new needle and give the drug. Wait a moment before removing the needle. 
  • Disposing of materials - securely dispose of the utilized needle and any other supplies. 
  • Dispose of used needles in a sturdy, sealed container that the needles cannot penetrate. Keep this container out of reach of children and pets. 

What is the recommended frequency for changing injection sites?

The frequency of rotating injection sites for Mounjaro can depend on the recommendations provided by your healthcare professional. However, it is best to avoid injecting in the same site each week. As a general guideline, it is advised to change the injection site weekly to avoid any bruising, irritation, or swelling. For instance, you might rotate between the abdomen, thigh, and upper arm. Keep a record of where you administer each injection to ensure you rotate through different body areas. 

Are there any side effects with Mounjaro

Taking Mounjaro can cause side effects such as nausea, diarrhea, loss of appetite, vomiting, constipation, indigestion, and stomach pain. If you are taking Mounjaro, a comprehensive lifestyle program, like the Mayo Clinic Diet for Weight-Loss Medication program, can help you achieve and maintain healthy weight loss for a lifetime. The program can be the support you need to optimize your Mounjaro journey. 

Need a prescription for GLP-1s? The Mayo Clinic Diet platform now offers access to clinical care for members seeking a prescription to weight-loss medication such as GLP-1s. Check if you're eligible for weight-loss medication.

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