How does Ozempic affect hormones?

There's a healthier way to lose weight with weight-loss medication. Discover the Mayo Clinic Diet for Weight-Loss Medications.

Ozempic is an FDA-approved medication for the treatment of obesity. It works by reducing appetite and increasing feelings of fullness. 

At the heart of Ozempic’s effectiveness lies its active ingredient, semaglutide. This remarkable compound belongs to the class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs mimic the actions of the naturally-occurring GLP-1 hormone. This gastrointestinal hormone plays a crucial role in regulating blood sugar levels and has a profound influence on weight management.

Effects of Ozempic on hormones:

  1. GLP-1 receptor activation: GLP-1 is a hormone produced in the gut in response to food intake. It has several effects on glucose metabolism and appetite regulation. Ozempic, a GLP-1 drug, activates the GLP-1 receptors in the body, particularly in the pancreas and the brain. 
  2. Insulin release: One of the main actions of GLP-1 is to stimulate the release of insulin from the pancreas. Insulin helps to lower blood sugar levels by promoting the uptake of glucose into cells. By mimicking GLP-1, Ozempic enhances insulin secretion in response to elevated blood glucose levels. 
  3. Glucagon suppression: GLP-1 drugs such as Ozempic also inhibit the release of glucagon, another hormone produced by the pancreas. Glucagon raises blood sugar levels by promoting the release of glucose from the liver. By suppressing glucagon, Ozempic helps to reduce excessive glucose production. 
  4. Gastric emptying: Ozempic can slow down how quickly the stomach empties after eating. This helps regulate the speed at which food is digested and absorbed, leading to a more gradual and controlled rise in blood sugar levels after meals. 
  5. Appetite regulation: GLP-1 plays a role in appetite regulation by acting on the brain’s appetite center. Ozempic has been associated with appetite suppression, and individuals taking this medication may experience a reduction in hunger and increased feelings of fullness. 

These hormone-related effects can help you improve blood sugar control and lose weight.  

Common side effects

As with most medications, weight-loss medications like Ozempic may come with side effects. Common side effects include nausea, vomiting, and stomach upsets. Many of the effects are mild and temporary.

You can reduce the risk of many common side effects by working closely with your prescribing provider to ensure you take the correct dose of medication, are eating a well-balanced diet, and drinking enough water. 

It is essential to follow a nutrition and healthy habits program like the Mayo Clinic Diet. Adhering to a healthy lifestyle program can help you manage or prevent the potential side effects. 

Note: Do not use Ozempic if you or any of your family have ever had medullary thyroid cancer (MTC) or if you have multiple endocrine neoplasia, type 2 (MEN 2). 

Need a prescription for GLP-1s? The Mayo Clinic Diet platform now offers access to clinical care for members seeking a prescription to weight-loss medication such as GLP-1s. Check if you're eligible for weight-loss medication.

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